Ryan Royster hit a 2-out, 3-run shot over the wall in left field in the bottom of the 12th to give the Catfish their 7th win in 9 games.
Cesar Suarez and Nevin Ashley laced consecutive singles before Royster slugged his 17th homer. The 20-year-old left fielder was a South Atlantic League All-Star and is hitting .315 through 100 games.
Ashley and Suarez also scored on second baseman Greg Buchanan's error in the sixth and Ashley lined an RBI single in the first for the Catfish (24-16).
Hunter Davis (1-0) allowed one hit over two scoreless innings for the win. Starter Ryan Morse yielded one run on four hits and three walks with a pair of strikeouts over six frames.
Catfish manager Jim Morrison was ejected in the 4th inning, arguing a home run by Lexington's Jordan Parraz. The Catfish skipper insisted the ball was foul, while home plate umpire Anthony Johnson insisted it was fair. The umpire won the argument. The Catfish won the game.