Hellickson (5-2) yielded two runs on six hits and a pair of walks with four strikeouts. The 20-year-old right-hander is 3-0 in six starts against the Braves (2-5), allowing just four earned runs over 35 innings.
Ryan Owen gave up a hit and struck out two over 2 1/3 scoreless frames to notch his sixth save for the Catfish (5-2).
Matthew Fields went 2-for-4 with three RBIs and Desmond Jennings cranked a three-run homer, his sixth, in the sixth for Columbus.
The win keeps the Catfish in 3rd place, 1/2 game behind division leaders Asheville and Greenville.
The series in Rome concludes tonight. The Catfish head to Savannah for 4 games starting Saturday.